Muscle soreness in legs, hips, wrists have seemed to be my life. In 10 years from now if we have 10's of millions of people with cancer and liver disease what will they say then. The starting dose for most adults is 5 mg once daily. This can increase the... Simvastatin may cause liver problems and using it with substantial quantities of alcohol may... View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. Bai X, Zhang B, Wang P, Wang GL, Li JL, Wen DS, Long XZ, Sun HS, Liu YB, Huang M, Zhong SL. Be careful and take care of your health and by that I do not mean taking more medications. Crestor. Results: A total of 61 patients were enrolled (41 women, 20 men; mean [SD] age, 60 [10] years; 5-mg/d dose, 25 patients; 10-mg/d dose, 36 patients). I spend most of my days in a chair. This prospective, open-label pilot study was conducted in consecutively referred male and female patients aged 38 to 80 years with primary high LDL-C (mean, 177 mg/dL) at The Cholesterol Center, Jewish Hospital, Cincinnati, Ohio. Stopped taking the pill, and symptoms disappeared. Lipitor may be taken with or without food and at any time of day. Statins and Abnormal Liver Function Tests: Is There a Correlation? In a matter of two years I poisoned myself into an invalid. View more. Up every two hours to pee like clockwork, sometimes more irritable for no apparent reason and irregular heart beats I can feel, and are picked up by my BP machine. Be careful and take care of your health and by that I do not mean taking more medications. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. Dr. Randee Lipman answered. There seems to be medication manufacturer/retail people posting here touting how great medications are. Expanding options with a wider range of rosuvastatin doses. lipitor 5 mg dosage. Atorvastatin rated 4.4/10 vs Crestor rated 6.0/10 in overall patient satisfaction. Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites. It is too painful to walk. Over the years I've been on one cholesterol drug or another. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. This trial was designed to compare the efficacy of atorvastatin 10 mg with simvastatin 10 mg and 20 mg, the latter dose being commonly used in some countries. Complained about pain and dizziness. At 40 mg, I experienced numbness, tingling, and burning in my toes and fingers. Hypothesis: The study was undertaken to compare the efficacy and tolerability of simvastatin 20 and 40 mg/day and atorvastatin 10 and 20 mg/day. I experienced similar issues when taking lipitor 40mg as well. Is not subject to the Controlled Substances Act. Cold fingers and feet as well. I was on it for two years. Get off Simvastatin immediately when you feel pain. Clin Ther. My numbers are down and acceptable to my GP. Please try all the lifestyle options before drugs. I spend most of my days in a chair. Myalgia, a predominant AE, had caused 50 patients to previously discontinue treatment with atorvastatin; 30, simvastatin; 19, pravastatin; 5… Muscle soreness in legs, hips, wrists have seemed to be my life. Please try all the lifestyle options before drugs. Then after about twenty-two months I felt something crystalize in my legs muscles. Harley CR, Gandhi S, Blasetto J, Heien H, Sasane R, Nelson SP. Twelve-week, multicenter, randomized, open-label comparison of the effects of rosuvastatin 10 mg/d and atorvastatin 10 mg/d in high-risk adults: a DISCOVERY study. Background: Atorvastatin, a new enantiomerically pure synthetic statin, has shown a marked low-density lipoprotein (LDL) cholesterol reduction at doses ranging from 10 to 80 mg/d. For High Cholesterol: Interesting reviews. Zocor costs almost $25 to $40 per month while on the other hand Lipitor cost $5 to $10 … Am J Geriatr Pharmacother. The cost difference is another factor that can help with the Atorvastatin vs Simvastatin comparison. Complained about pain and dizziness. Lipitor that is available in 10, 20,40 and 80 mg while the Zocor is present in the 5, 20, 20, 40, 80 mg dosages. Atorvastatin is effective at lowering cholesterol; however, its use may be limited by side effects such as muscle pain. There seems to be medication manufacturer/retail people posting here touting how great medications are. For High Cholesterol: I have been taking statins for 3 years now and this site rates up there as a good resource for medication experience. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. End points included acceptability (assessed using patient-initiated discontinuation of rosuvastatin), effectiveness (absolute and percentage reductions in LDL-C and triglycerides), and safety profile (aspartate and alanine aminotransferases [AST and ALT, respectively] >3 times the laboratory upper limit of normal [xULN] or elevations in creatine kinase [CK]>10xULN). In these 61 hypercholesterolemic patients unable to tolerate other statins and, subsequently in some cases, unable to meet LDL-C goals while receiving nonstatin LIT monotherapy, these preliminary observations suggest that rosuvastatin at doses of 5 and 10 mg/d+diet was well tolerated, effective, and had a good safety profile. Pain persisted. Rosuvastatin 5 mg/d was administered to patients categorized by NCEP ATP III risk stratification as moderately high risk, and rosuvastatin 10 mg/d was administered to patients categorized as high or very high risk. Commonly reported side effects include: Strandberg TE, Feely J, Sigurdsson EL; DISCOVERY study group. Up every two hours to pee like clockwork, sometimes more irritable for no apparent reason and irregular heart beats I can feel, and are picked up by my BP machine. For High Cholesterol: At 40 mg, I experienced numbness, tingling, and burning in my toes and fingers. Get off Simvastatin immediately when you feel pain. After reading these reviews, I'm going to self de-medicate for a spell to see if my sleep pattern changes as well as other possible side effects I've listed. NCI CPTC Antibody Characterization Program. There may be variations in CSA schedules between individual states. Atorvastatin rated 4.4/10 vs Simvastatin rated 5.0/10 in overall patient satisfaction. Clin Ther. My cholesterol reading 134. Patients with high levels of low-density lipoprotein cholesterol (LDL-C) might not tolerate 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors ("statins") because of adverse effects (AEs) and might not respond well enough to nonstatin lipid-lowering therapies (LLTs) to meet LDL-C goals. Statin Intolerance and Vitamin D Supplementation. hemorrhagic stroke, arthralgia, diarrhea, and nasopharyngitis. Cholesterol meds : The dosage of your cholesterol medication is based on your cholesterol levels. This occurred over a period of 3 weeks. Clipboard, Search History, and several other advanced features are temporarily unavailable. Eighteen patients subsequently failed to reach LDL-C goals with nonstatin LLT(s) alone (colesevelam, 10 patients; ezetimibe, 8; niacin extended release, 2; and fenofibrate, 1). Statins: Practical Considerations - A Review. The cost difference is another factor that can help with the Atorvastatin vs Simvastatin comparison. Health care employs more people with very high salaries than any other profession and to keep it going there is no telling what they may do. Compare Atorvastatin vs Simvastatin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. I had this Dr for more then forty years and never associated the medicine with my pain. Clin Ther. 2019 Apr;40(4):492-499. doi: 10.1038/s41401-018-0013-y. I had a muscle biopsy but I am unable to get the results. A total of 61 patients were enrolled (41 women, 20 men; mean [SD] age, 60 [10] years; 5-mg/d dose, 25 patients; 10-mg/d dose, 36 patients). Got Gabapentin and Vicadin. I have been in severe pain for the last eight years. Health care employs more people with very high salaries than any other profession and to keep it going there is no telling what they may do. My advice is to be aware of anyone making statements that taking medications over lifestyle change is the answer. Epub 2018 Jun 27. Hyperlipoproteinemia Type IIa, Elevated LDL, Hyperlipoproteinemia Type IIb, Elevated LDL VLDL, Hyperlipoproteinemia Type III, Elevated beta-VLDL IDL, Hyperlipoproteinemia Type IV, Elevated VLDL. Got Gabapentin and Vicadin. Of the 61 patients, 1 receiving the 10-mg/d dose discontinued rosuvastatin treatment because of unilateral muscular pain after 4 weeks; no AST or ALT levels were >3xULN, and no CK levels were >10xULN. This site needs JavaScript to work properly. It seems too many people have the same symptoms as me, and have stopped taking the medication with positive results. The other hand lipitor cost $ 5 to $ 40 per month while on other! Tingling, and burning in my toes and fingers something crystalize in my muscles. Simvastatin comparison medication with positive results get the results had this Dr for more then years... 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